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The probability of effect of apalutamide on modafinil exposure is low due to the existence of multiple pathways for modafinil metabolism plasma concentrations of modafinil may be impacted by strong CYP3A4 inducers. The probability of effect of apalutamide on modafinil exposure is low due to the existence of multiple pathways for modafinil metabolism plasma concentrations of modafinil may be impacted by strong CYP3A4 inducers. The cost for Provigil oral tablet 100 mg is around ,503 for a supply of 30 tablets, depending on the pharmacy you visit. The cost for Provigil oral tablet 100 mg is around ,503 for a supply of 30 tablets, depending on the pharmacy you visit. Norgestrel: (Major) Modafinil may cause failure of oral contraceptives or hormonal contraceptive-containing implants or devices due to induction of CYP3A4 isoenzyme metabolism of the progestins in these products. 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